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    fatty_acid
    beginner
    natural

    Omega-3 (DHA/EPA)

    Essential fatty acid critical for brain structure. DHA makes up ~40% of polyunsaturated fatty acids in the brain.

    48h half-life0 fat-soluble moderate

    Quick Facts

    Common Dose

    2000mg combined EPA+DHA

    Dose Range

    1000–3000mg

    Frequency

    1-2x daily with food

    Half-Life

    48 hours

    Onset

    —

    Duration

    —

    Cycling

    Not required

    Legal Status

    otc_supplement

    How It Works

    DHA integrates into neuronal cell membranes, improving fluidity and receptor function. EPA provides anti-inflammatory effects.

    Neurotransmitter Pathways

    cell_membrane_integrityanti_inflammatorybdnf

    Effects & Benefits

    neuroprotection
    mood
    memory
    anti_inflammation
    supports_all_pathways

    Dosing Guide

    Beginner
    1000mg combined EPA+DHA
    Standard
    2000mg combined EPA+DHA
    Advanced
    3000mg combined EPA+DHA

    💡 Fat-soluble — take with a fat source (e.g., fish oil, MCT oil) for better absorption.

    ⚠️ Start low and increase gradually. Individual responses vary.

    Side Effects & Safety

    Potential Side Effects

    Fishy burpsGI upsetMild blood thinning at high doses

    Contraindications

    Fish/shellfish allergyPre-surgery

    Drug Interactions

    blood_thinnershigh_dose_aspirin

    What the Community Says

    "Considered a non-negotiable foundation by the nootropics community."

    universally positive
    Community ranking: #15 most discussed

    Based on analysis of r/Nootropics, r/StackAdvice, and r/biohackers

    Research & Evidence

    DHA supplementation improved both memory and reaction time in healthy young adults

    2012 — American Journal of Clinical Nutrition

    Improved episodic and working memory in healthy 18-25 year olds

    PubMed

    Best Stacked With

    Where to Buy

    Estimated cost: $20/month

    Cycling Protocol

    No cycling required — can be taken daily.

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    Frequently Asked Questions

    Related Guides & Articles

    Check Interactions

    See how Omega-3 (DHA/EPA) interacts with other compounds in your stack.

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