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    cholinergic
    beginner
    semi synthetic

    CDP-Choline (Citicoline)

    Premium choline source that also provides uridine as a byproduct. Supports both acetylcholine synthesis and cell membrane repair.

    56h half-life 30min onset water-soluble moderate

    Quick Facts

    Common Dose

    250mg

    Dose Range

    200–500mg

    Frequency

    1-2x daily

    Half-Life

    56 hours

    Onset

    30 min

    Duration

    12 hours

    Cycling

    Not required

    Legal Status

    otc_supplement

    How It Works

    Metabolized into choline and cytidine (which converts to uridine). Choline feeds acetylcholine production. Uridine supports phospholipid synthesis and dopamine receptor density.

    Neurotransmitter Pathways

    acetylcholinedopaminephospholipid_synthesis

    Effects & Benefits

    focus
    mental_energy
    memory
    neuroprotection

    Dosing Guide

    Beginner
    200mg
    Standard
    250mg
    Advanced
    500mg

    ⚠️ Start low and increase gradually. Individual responses vary.

    Side Effects & Safety

    Potential Side Effects

    Rare: headache, GI upset, insomnia if taken too late

    Drug Interactions

    levodopa

    What the Community Says

    "Frequently cited as the cleanest choline source. Users praise the non-stimulant energy boost."

    very positive
    Community ranking: #8 most discussed

    Based on analysis of r/Nootropics, r/StackAdvice, and r/biohackers

    Research & Evidence

    Citicoline improves memory performance in elderly subjects

    2012 — International Journal of Food Sciences and Nutrition

    Improved delayed recall and recognition memory in elderly subjects over 12 weeks

    PubMed

    Best Stacked With

    Avoid Pairing With

    Available In These Products

    Cycling Protocol

    No cycling required — can be taken daily.

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    Frequently Asked Questions

    Related Guides & Articles

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