Research Use Only

    This site is an independent educational resource for research compounds. We do not sell, distribute, or endorse human consumption of any compound. By entering, you confirm you are 21 years of age or older and agree to our Terms & Privacy Policy.

    🔬 93K+ researchers trust BodyHackGuide — Join r/BodyHackGuide
    mineral
    intermediate
    mineral

    Lithium Orotate

    Micro-dose lithium for neuroprotection and mood stabilization. The #1 most praised nootropic in a recent 800+ comment Reddit thread.

    24h half-life 60min onset water-soluble budget

    Quick Facts

    Common Dose

    5mg elemental lithium

    Dose Range

    5–20mg

    Frequency

    1x daily

    Half-Life

    24 hours

    Onset

    60 min

    Duration

    24 hours

    Cycling

    Not required

    Legal Status

    otc_supplement

    How It Works

    Inhibits GSK-3beta which upregulates BDNF and promotes neuroplasticity. Modulates inositol signaling. Orotate carrier enables lower effective doses.

    Neurotransmitter Pathways

    gsk3bbdnfinositolglutamate

    Effects & Benefits

    mood_stabilization
    anxiety_reduction
    neuroprotection
    anti_rumination

    Dosing Guide

    Beginner
    5mg elemental lithium
    Standard
    5mg elemental lithium
    Advanced
    20mg elemental lithium

    ⚠️ Start low and increase gradually. Individual responses vary.

    Side Effects & Safety

    Potential Side Effects

    Mild thirstIncreased urination

    Contraindications

    Kidney diseaseThyroid disordersPregnancy

    Drug Interactions

    nsaidsdiureticsace_inhibitorsssris

    What the Community Says

    "The single most praised nootropic in a massive Reddit thread. Users describe it as life-changing for anxiety, depression, and intrusive thoughts at just 5mg/day."

    overwhelmingly positive
    Community ranking: #1 most discussed

    Based on analysis of r/Nootropics, r/StackAdvice, and r/biohackers

    Research & Evidence

    Lithium in drinking water and crime, suicide, drug arrest incidences

    2009 — Biological Trace Element Research

    Higher trace lithium correlated with lower suicide and crime rates

    PubMed

    Lithium in drinking water and dementia incidence

    2017 — British Journal of Psychiatry

    Higher lithium exposure associated with lower dementia incidence

    PubMed

    Best Stacked With

    Avoid Pairing With

    Where to Buy

    Estimated cost: $8/month

    Cycling Protocol

    No cycling required — can be taken daily.

    Get the complete research brief for Lithium Orotate

    PubMed citations, dosing protocols, interaction data, and stacking recommendations — delivered to your inbox.

    Frequently Asked Questions

    Related Guides & Articles

    Check Interactions

    See how Lithium Orotate interacts with other compounds in your stack.

    Want expert guidance?

    Get a personalized protocol from an experienced coach.