Research Use Only

    This site is an independent educational resource for research compounds. We do not sell, distribute, or endorse human consumption of any compound. By entering, you confirm you are 21 years of age or older and agree to our Terms & Privacy Policy.

    🔬 93K+ researchers trust BodyHackGuide — Join r/BodyHackGuide
    adaptogen
    beginner
    natural

    Lions Mane Mushroom

    Medicinal mushroom that stimulates NGF and BDNF. One of the few natural compounds with genuine neurogenesis potential. Long-term play, not an acute focus booster.

    6h half-life 60min onset water-soluble moderate

    Quick Facts

    Common Dose

    1000mg

    Dose Range

    500–3000mg

    Frequency

    1-2x daily

    Half-Life

    6 hours

    Onset

    60 min

    Duration

    8 hours

    Cycling

    Not required

    Legal Status

    otc_supplement

    How It Works

    Contains hericenones and erinacines that cross the BBB and stimulate NGF synthesis. Promotes neurogenesis, myelination, and synaptic plasticity.

    Neurotransmitter Pathways

    ngfbdnfacetylcholine

    Effects & Benefits

    neurogenesis
    memory
    mood
    neuroprotection

    Dosing Guide

    Beginner
    500mg
    Standard
    1000mg
    Advanced
    3000mg

    ⚠️ Start low and increase gradually. Individual responses vary.

    Side Effects & Safety

    Potential Side Effects

    Mild GI discomfortRare: skin itchiness from increased NGF

    Contraindications

    Mushroom allergiesBleeding disorders

    Drug Interactions

    blood_thinnersdiabetes_meds

    What the Community Says

    "Frequently recommended for long-term brain health. Users note improved verbal recall and mood stability after 2-4 weeks."

    very positive
    Community ranking: #4 most discussed

    Based on analysis of r/Nootropics, r/StackAdvice, and r/biohackers

    Research & Evidence

    Improving effects of Yamabushitake on mild cognitive impairment

    2009 — Phytotherapy Research

    Significant cognitive improvement in MCI patients over 16 weeks

    PubMed

    Best Stacked With

    Where to Buy

    Estimated cost: $20/month

    Cycling Protocol

    No cycling required — can be taken daily.

    Get the complete research brief for Lions Mane Mushroom

    PubMed citations, dosing protocols, interaction data, and stacking recommendations — delivered to your inbox.

    Frequently Asked Questions

    Related Guides & Articles

    Check Interactions

    See how Lions Mane Mushroom interacts with other compounds in your stack.

    Want expert guidance?

    Get a personalized protocol from an experienced coach.