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    phospholipid
    beginner
    natural

    Phosphatidylserine (PS)

    Key phospholipid in neuronal cell membranes. Supports cortisol regulation, memory, and cognitive processing speed. FDA-qualified health claim.

    12h half-life 30min onset fat-soluble moderate

    Quick Facts

    Common Dose

    100mg

    Dose Range

    100–300mg

    Frequency

    1-3x daily

    Half-Life

    12 hours

    Onset

    30 min

    Duration

    12 hours

    Cycling

    Not required

    Legal Status

    otc_supplement

    How It Works

    Integral component of cell membranes. Supports neurotransmitter release, receptor function, and signal transduction. Blunts cortisol response.

    Neurotransmitter Pathways

    cell_membrane_integritycortisolacetylcholine

    Effects & Benefits

    memory
    cortisol_reduction
    processing_speed
    focus

    Dosing Guide

    Beginner
    100mg
    Standard
    100mg
    Advanced
    300mg

    💡 Fat-soluble — take with a fat source (e.g., fish oil, MCT oil) for better absorption.

    ⚠️ Start low and increase gradually. Individual responses vary.

    Side Effects & Safety

    Potential Side Effects

    GI upset at high dosesInsomnia if taken at night

    Contraindications

    Blood thinning medications

    Drug Interactions

    blood_thinnersanti_inflammatory_drugs

    What the Community Says

    "Respected foundational brain health supplement. Users appreciate cortisol-lowering effects."

    positive
    Community ranking: #20 most discussed

    Based on analysis of r/Nootropics, r/StackAdvice, and r/biohackers

    Research & Evidence

    The effects of phosphatidylserine on cognitive function

    2015 — Journal of Clinical Biochemistry and Nutrition

    Improved memory recognition and recall in elderly subjects

    PubMed

    Best Stacked With

    Where to Buy

    Estimated cost: $18/month

    Cycling Protocol

    No cycling required — can be taken daily.

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    Frequently Asked Questions

    Related Guides & Articles

    Check Interactions

    See how Phosphatidylserine (PS) interacts with other compounds in your stack.

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