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    peptide_derived
    intermediate
    synthetic

    Noopept

    Dipeptide derived from cycloprolylglycine. Up to 1000x more potent than piracetam by weight. Enhances BDNF and NGF expression.

    0.5h half-life 5min onset water-soluble budget

    Quick Facts

    Common Dose

    20mg

    Dose Range

    10–40mg

    Frequency

    2-3x daily (sublingual preferred)

    Half-Life

    0.5 hours

    Onset

    5 min

    Duration

    3 hours

    Cycling

    Required

    Legal Status

    research_chemical

    How It Works

    Modulates AMPA and NMDA receptors. Increases BDNF and NGF expression. Enhances acetylcholine signaling. Neuroprotective effects.

    Neurotransmitter Pathways

    glutamateacetylcholinebdnfngf

    Effects & Benefits

    memory
    focus
    learning_speed
    neuroprotection
    verbal_fluency

    Dosing Guide

    Beginner
    10mg
    Standard
    20mg
    Advanced
    40mg

    ⚠️ Start low and increase gradually. Individual responses vary.

    Cycling Protocol

    56 days on / 4 days off (based on original Russian clinical protocol).

    Tolerance Risk:
    low

    Side Effects & Safety

    Potential Side Effects

    IrritabilityHeadache (without choline)Brain fog at high dosesInsomnia

    Contraindications

    HypertensionPregnancy

    Drug Interactions

    blood_pressure_meds

    What the Community Says

    "Praised for improving verbal fluency and memory at very low doses. Sublingual administration is strongly preferred."

    positive
    Community ranking: #10 most discussed

    Based on analysis of r/Nootropics, r/StackAdvice, and r/biohackers

    Research & Evidence

    Noopept stimulates the expression of NGF and BDNF in rat hippocampus

    2008 — Bulletin of Experimental Biology and Medicine

    Chronic administration increased both NGF and BDNF mRNA expression

    PubMed

    Best Stacked With

    Available In These Products

    Cycling Schedule

    56 days on / 4 days off (based on original Russian clinical protocol).

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