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    cholinergic
    intermediate
    natural

    Huperzine A

    Potent and selective acetylcholinesterase inhibitor from Chinese club moss. Very long-lasting — must be dosed carefully and cycled.

    10h half-life 30min onset water-soluble budget

    Quick Facts

    Common Dose

    0.1mg

    Dose Range

    0.05–0.2mg

    Frequency

    Every other day or 2-3x per week

    Half-Life

    10 hours

    Onset

    30 min

    Duration

    14 hours

    Cycling

    Required

    Legal Status

    otc_supplement

    How It Works

    Reversible inhibitor of acetylcholinesterase. Increases acetylcholine availability and duration. NMDA receptor antagonist properties.

    Neurotransmitter Pathways

    acetylcholine

    Effects & Benefits

    memory
    learning
    focus
    neuroprotection

    Dosing Guide

    Beginner
    0.05mg
    Standard
    0.1mg
    Advanced
    0.2mg

    ⚠️ Start low and increase gradually. Individual responses vary.

    Cycling Protocol

    2-4 weeks on / 1-2 weeks off. Or dose every other day. Long half-life means accumulation.

    Tolerance Risk:
    low

    Side Effects & Safety

    Potential Side Effects

    NauseaDiarrheaExcessive cholinergic activityVivid dreams/nightmares

    Contraindications

    Heart conditionsGI ulcersAsthma

    Drug Interactions

    cholinergic_drugsanticholinergicsbeta_blockers

    What the Community Says

    "Respected for memory but community is cautious about stacking with other cholinergics."

    positive with_caution
    Community ranking: #24 most discussed

    Based on analysis of r/Nootropics, r/StackAdvice, and r/biohackers

    Research & Evidence

    Huperzine A for Alzheimers disease: A systematic review

    2013 — PLoS One

    Significant improvements in cognitive function in AD patients

    PubMed

    Best Stacked With

    Avoid Pairing With

    Available In These Products

    Cycling Schedule

    2-4 weeks on / 1-2 weeks off. Or dose every other day. Long half-life means accumulation.

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    Frequently Asked Questions

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