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    amino_acid
    beginner
    semi synthetic

    Creatine Monohydrate

    The most studied supplement in sports science history. Provides rapid ATP regeneration in both muscle and brain.

    180h half-life0 water-soluble budget

    Quick Facts

    Common Dose

    5000mg

    Dose Range

    3000–5000mg

    Frequency

    1x daily

    Half-Life

    180 hours

    Onset

    —

    Duration

    —

    Cycling

    Not required

    Legal Status

    otc_supplement

    How It Works

    Phosphocreatine serves as a rapid ATP buffer. Brain cells use creatine kinase to regenerate ATP during high cognitive demand.

    Neurotransmitter Pathways

    atp_energyneuroprotection

    Effects & Benefits

    mental_energy
    working_memory
    anti_fatigue
    physical_performance

    Dosing Guide

    Beginner
    3000mg
    Standard
    5000mg
    Advanced
    5000mg

    ⚠️ Start low and increase gradually. Individual responses vary.

    Side Effects & Safety

    Potential Side Effects

    Water retentionGI upset if taken dryRare: hair thinning debate

    Contraindications

    Kidney disease

    Drug Interactions

    nephrotoxic_drugs

    What the Community Says

    "Increasingly discussed as a cognitive supplement. Vegetarians report the most dramatic cognitive benefits."

    very positive
    Community ranking: #17 most discussed

    Based on analysis of r/Nootropics, r/StackAdvice, and r/biohackers

    Research & Evidence

    Creatine supplementation and cognitive functioning of vegetarians and omnivores

    2011 — British Journal of Nutrition

    Significantly improved memory and intelligence in vegetarians

    PubMed

    Best Stacked With

    Where to Buy

    Estimated cost: $8/month

    Cycling Protocol

    No cycling required — can be taken daily.

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    Frequently Asked Questions

    Related Guides & Articles

    Check Interactions

    See how Creatine Monohydrate interacts with other compounds in your stack.

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