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The worlds most widely used psychoactive compound. Blocks adenosine receptors to promote wakefulness. Response varies significantly based on CYP1A2 genetics.
Common Dose
100mg
Dose Range
50–400mg
Frequency
1-2x daily, avoid after 2pm
Half-Life
5 hours
Onset
15 min
Duration
6 hours
Cycling
Required
Legal Status
otc_supplement
Antagonizes adenosine A1 and A2A receptors, increasing dopamine and norepinephrine signaling.
Neurotransmitter Pathways
⚠️ Start low and increase gradually. Individual responses vary.
5 days on / 2 days off, or 2 weeks on / 1 week off. Full reset takes 7-12 days.
Potential Side Effects
Contraindications
Drug Interactions
"Universally acknowledged as effective but many users discuss tolerance management and the importance of pairing with L-Theanine."
Based on analysis of r/Nootropics, r/StackAdvice, and r/biohackers
Effects of caffeine on cognitive performance under sleep deprivation
2016 — Nutritional Neuroscience
Improved reaction time and vigilance during sleep deprivation
PubMedEstimated cost: $5/month
5 days on / 2 days off, or 2 weeks on / 1 week off. Full reset takes 7-12 days.
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