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    vitamin_derivative
    intermediate
    synthetic

    Sulbutiamine

    Synthetic derivative of Vitamin B1. Crosses the BBB. Known for reducing psycho-behavioral inhibition.

    5h half-life 30min onset fat-soluble moderate

    Quick Facts

    Common Dose

    400mg

    Dose Range

    200–600mg

    Frequency

    1x daily, morning

    Half-Life

    5 hours

    Onset

    30 min

    Duration

    6 hours

    Cycling

    Required

    Legal Status

    otc_supplement

    How It Works

    Increases brain thiamine levels. Modulates dopaminergic and glutamatergic transmission. Upregulates D1 dopamine receptor density in PFC.

    Neurotransmitter Pathways

    dopamineglutamatethiamine

    Effects & Benefits

    motivation
    social_confidence
    anti_fatigue
    mood

    Dosing Guide

    Beginner
    200mg
    Standard
    400mg
    Advanced
    600mg

    💡 Fat-soluble — take with a fat source (e.g., fish oil, MCT oil) for better absorption.

    ⚠️ Start low and increase gradually. Individual responses vary.

    Cycling Protocol

    5 days on / 2 days off. Tolerance develops relatively quickly.

    Tolerance Risk:
    moderate

    Side Effects & Safety

    Potential Side Effects

    HeadacheInsomniaIrritability at high doses

    What the Community Says

    "Praised for unique effect on social confidence and motivation. Removes the brake pedal on social interaction."

    positive
    Community ranking: #19 most discussed

    Based on analysis of r/Nootropics, r/StackAdvice, and r/biohackers

    Research & Evidence

    Sulbutiamine decreases psycho-behavioral inhibition in major depression

    2003 — L'Encéphale

    Significant reduction in psycho-behavioral inhibition as adjunctive treatment

    PubMed

    Best Stacked With

    Where to Buy

    Estimated cost: $20/month

    Cycling Schedule

    5 days on / 2 days off. Tolerance develops relatively quickly.

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    Frequently Asked Questions

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