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Oleamide is an endogenous fatty acid amide that accumulates in cerebrospinal fluid during sleep deprivation. It acts on cannabinoid and serotonin receptors to promote sleep onset without habit formation or morning grogginess.
Common Dose
200mg
Dose Range
100–400mg
Frequency
before bed
Half-Life
6 hours
Onset
30 min
Duration
8 hours
Cycling
Not required
Legal Status
legal
Oleamide is a full agonist at CB1 cannabinoid receptors and a positive allosteric modulator of 5-HT2A and GABA-A receptors. It also inhibits FAAH, increasing endocannabinoid tone.
Neurotransmitter Pathways
💡 Fat-soluble — take with a fat source (e.g., fish oil, MCT oil) for better absorption.
⚠️ Start low and increase gradually. Individual responses vary.
Potential Side Effects
Contraindications
Drug Interactions
"Growing interest as a natural sleep aid. Users report it feels like a mild, clean version of cannabis-induced sleepiness without cognitive fog."
Based on analysis of r/Nootropics, r/StackAdvice, and r/biohackers
Oleamide: an endogenous sleep-inducing lipid
2001 — Current Medicinal Chemistry
Identified oleamide as an endogenous sleep factor.
PubMedNo cycling required — can be taken daily.
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