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Apigenin is a natural flavonoid found in chamomile, parsley, and celery. It acts as a mild sedative and anxiolytic through GABA-A receptor modulation. Popularized by Andrew Huberman for sleep without morning grogginess.
Common Dose
50mg
Dose Range
25–100mg
Frequency
before bed
Half-Life
12 hours
Onset
30 min
Duration
8 hours
Cycling
Not required
Legal Status
legal
Apigenin binds to the benzodiazepine site on GABA-A receptors as a partial agonist. It also inhibits CD38 (increasing NAD+ levels) and has anti-inflammatory properties.
Neurotransmitter Pathways
💡 Fat-soluble — take with a fat source (e.g., fish oil, MCT oil) for better absorption.
⚠️ Start low and increase gradually. Individual responses vary.
Potential Side Effects
Contraindications
Drug Interactions
"One of the most recommended sleep supplements on Reddit, boosted by Huberman podcast. Non-habit-forming with longevity benefits."
Based on analysis of r/Nootropics, r/StackAdvice, and r/biohackers
No cycling required — can be taken daily.
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