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    gabaergic
    advanced
    synthetic

    Phenibut

    GABA derivative developed in Russia. Potent anxiolytic and social enhancer. HIGHLY addictive with severe withdrawal potential. Requires extreme caution.

    5h half-life 60min onset water-soluble budget

    Quick Facts

    Common Dose

    500mg

    Dose Range

    250–1000mg

    Frequency

    MAX 1-2x per week. NEVER daily.

    Half-Life

    5 hours

    Onset

    60 min

    Duration

    8 hours

    Cycling

    Required

    Legal Status

    research_chemical

    How It Works

    Agonist at GABA-B receptors. Also modulates voltage-dependent calcium channels. Crosses BBB due to phenyl ring.

    Neurotransmitter Pathways

    gaba_bcalcium_channels

    Effects & Benefits

    anxiety_elimination
    social_enhancement
    euphoria
    sleep

    Dosing Guide

    Beginner
    250mg
    Standard
    500mg
    Advanced
    1000mg

    ⚠️ Start low and increase gradually. Individual responses vary.

    Cycling Protocol

    CRITICAL: Maximum 1-2 times per week. NEVER use daily. Withdrawal can be life-threatening.

    Tolerance Risk:
    extreme

    Side Effects & Safety

    Potential Side Effects

    DrowsinessDizzinessNauseaSEVERE physical dependenceWithdrawal seizures possible

    Contraindications

    History of substance abuseLiver diseaseKidney diseaseEpilepsy

    Drug Interactions

    alcoholbenzodiazepinesopioidsgabapentinpregabalinall_sedatives

    What the Community Says

    "Extremely divisive. Users who follow strict protocols report effectiveness, but withdrawal horror stories dominate."

    polarizing with_strong_warnings
    Community ranking: #8 most discussed

    Based on analysis of r/Nootropics, r/StackAdvice, and r/biohackers

    Research & Evidence

    Phenibut addiction: A case report

    2013 — Therapeutic Advances in Psychopharmacology

    Case report documenting severe withdrawal including psychosis

    PubMed

    Avoid Pairing With

    Available In These Products

    Cycling Schedule

    CRITICAL: Maximum 1-2 times per week. NEVER use daily. Withdrawal can be life-threatening.

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    Frequently Asked Questions

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