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    LongevityPhase II

    NAD+ Dosage Guide: Protocols, Calculator & Safety

    Everything you need to know about NAD+ dosing — protocols, safety, and where to buy.

    Dose Range

    50,000–500,000 mcg (50–500 mg) per injection; higher for IV infusions

    Frequency

    2–3 times per week subcutaneous; weekly-monthly IV infusions

    Cycle Length

    4–12 weeks; many use ongoing maintenance dosing

    Half-Life

    ~1–2 hours IV; subcutaneous absorption extends effective window

    Administration Routes

    SubcutaneousIntramuscularIntravenousOral (precursors)

    Quick Reconstitution Calculator

    Calculate syringe units instantly

    Syringe Draw

    10.0 units

    2500 mcg/ml · 0.100 ml draw

    Full Tool

    Dosing Protocols

    Beginner
    100 mg subcutaneous 2x/week for 4 weeks.
    Standard
    250 mg subcutaneous 3x/week for 8 weeks, or 500 mg IV infusion once monthly.
    Advanced
    500 mg subcutaneous daily for loading (2 weeks), then 250 mg 3x/week maintenance. Can alternate with IV infusions.

    Weight-Based Dosing

    Not strictly weight-based. Clinical protocols use standard doses.

    Commonly Stacked With

    Pairs with MOTS-C for mitochondrial optimization. Combines with Epithalon for comprehensive anti-aging. Stacks with Semax/Selank for neuroprotection. Can complement GH peptides for recovery.

    Side Effects & Safety

    Well-tolerated at standard doses. Flushing (IV/injection), headache, mild nausea, fatigue during initial loading, insomnia if taken late. Transient anxiety in some users.

    Contraindications

    Active cancer (NAD+ supports rapidly dividing cells). Severe liver or kidney disease. Bipolar disorder (may trigger mania). Pregnancy or breastfeeding.

    Check interactions with the Interaction Checker →

    Additional Notes

    Subcutaneous injections are gaining popularity over IV (more practical, less expensive). IV infusions (250–1000 mg) are offered in longevity clinics but take 2–4 hours. NAD+ precursors (NMN, NR) are oral alternatives but with lower direct NAD+ elevation. Stinging/burning at injection site is common and normal.

    Where to Buy NAD+

    Compare 5 listings across 5 vendors — from $29.99

    Frequently Asked Questions

    What is the recommended NAD+ dosage?

    The typical dose range for NAD+ is 50,000–500,000 mcg (50–500 mg) per injection; higher for IV infusions. It is usually administered 2–3 times per week subcutaneous; weekly-monthly IV infusions. Always start with the lowest effective dose.

    How often should I take NAD+?

    2–3 times per week subcutaneous; weekly-monthly IV infusions

    Does NAD+ need to be cycled?

    Yes, typical cycle length is 4–12 weeks; many use ongoing maintenance dosing.

    What are NAD+ side effects?

    Well-tolerated at standard doses. Flushing (IV/injection), headache, mild nausea, fatigue during initial loading, insomnia if taken late. Transient anxiety in some users.

    Where can I buy NAD+?

    Compare 5 listings from 5 vendors on our price comparison page — starting from $29.99.

    NAD+ Full Profile

    Research data, mechanisms, and pricing

    Interaction Checker

    Check drug & compound interactions