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    Longevity & Cellular HealthPhase I

    MOTS-c Dosage Guide: Protocols, Calculator & Safety

    Everything you need to know about MOTS-c dosing — protocols, safety, and where to buy.

    Dose Range

    5,000–10,000 mcg (5–10 mg) per injection

    Frequency

    3–5 times per week

    Cycle Length

    4–8 weeks

    Half-Life

    ~4–6 hours

    Administration Routes

    SubcutaneousIntramuscular

    Quick Reconstitution Calculator

    Calculate syringe units instantly

    Syringe Draw

    10.0 units

    2500 mcg/ml · 0.100 ml draw

    Full Tool

    Dosing Protocols

    Beginner
    5 mg subcutaneous 3x/week for 4 weeks.
    Standard
    5–10 mg subcutaneous 5x/week for 6 weeks.
    Advanced
    10 mg daily for 8 weeks. Can combine with NAD+ for comprehensive mitochondrial support.

    Weight-Based Dosing

    Not established. Standard flat dosing.

    Commonly Stacked With

    Natural pairing with Humanin for comprehensive mitochondrial-derived peptide protocol. Stacks well with NAD+ and exercise for synergistic AMPK activation.

    Side Effects & Safety

    Well-tolerated. Occasional GI discomfort, bloating, mild nausea. Rare: injection site reactions, hypoglycemia (enhances insulin sensitivity), muscle cramping.

    Contraindications

    Active cancer. Severe diabetes without monitoring. Pregnancy or breastfeeding.

    Check interactions with the Interaction Checker →

    Additional Notes

    Sometimes called an "exercise mimetic" due to AMPK activation. Endogenous MOTS-C levels decline with age and are elevated during exercise. Best administered in the morning or pre-workout. Can be taken alongside exercise for additive metabolic benefits.

    Where to Buy MOTS-c

    Compare 5 listings across 4 vendors — from $44.99

    Frequently Asked Questions

    What is the recommended MOTS-c dosage?

    The typical dose range for MOTS-c is 5,000–10,000 mcg (5–10 mg) per injection. It is usually administered 3–5 times per week. Always start with the lowest effective dose.

    How often should I take MOTS-c?

    3–5 times per week

    Does MOTS-c need to be cycled?

    Yes, typical cycle length is 4–8 weeks.

    What are MOTS-c side effects?

    Well-tolerated. Occasional GI discomfort, bloating, mild nausea. Rare: injection site reactions, hypoglycemia (enhances insulin sensitivity), muscle cramping.

    Where can I buy MOTS-c?

    Compare 5 listings from 4 vendors on our price comparison page — starting from $44.99.

    MOTS-c Full Profile

    Research data, mechanisms, and pricing

    Interaction Checker

    Check drug & compound interactions

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