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HGH Fragment 176-191
Metabolic & Weight LossPhase 2HGH Fragment 176-191 is a stabilized peptide fragment of the C-terminus of human growth hormone, corresponding to amino acids 176–191 with a tyrosine addition at the N-terminus. It retains the lipolytic activity of full GH but lacks GH's effects on insulin resistance, IGF-1 stimulation, and cellular proliferation.
Overview
Key Takeaways
- →Targeted fat loss
- →Visceral fat reduction
- →No insulin resistance
At A Glance
The 176-191 fragment activates the fat-metabolizing (lipolytic) signaling pathway through GH receptor interactions without stimulating the IGF-1 axis. It inhibits lipogenesis from glucose in adipocytes and enhances fat breakdown by upregulating hormone-sensitive lipase activity, particularly in visceral fat depots. In rodent studies, it demonstrates 12.5x greater lipolytic potency than full GH at equivalent molar concentrations.
The 176-191 fragment activates the fat-metabolizing (lipolytic) signaling pathway through GH receptor interactions without stimulating the IGF-1 axis. It inhibits lipogenesis from glucose in adipocytes and enhances fat breakdown by upregulating hormone-sensitive lipase activity, particularly in visceral fat depots. In rodent studies, it demonstrates 12.5x greater lipolytic potency than full GH at equivalent molar concentrations.
Overview
HGH Fragment 176-191 is a stabilized peptide fragment of the C-terminus of human growth hormone, corresponding to amino acids 176–191 with a tyrosine addition at the N-terminus. It retains the lipolytic activity of full GH but lacks GH's effects on insulin resistance, IGF-1 stimulation, and cellular proliferation. Developed specifically as a safer fat-loss alternative to HGH.
Potential Benefits
Potential Research Fields
Chemical Information
IUPAC Name
Tyr-hGH(176-191)
CAS Number
66004-57-7
Molecular Formula
C78H123N23O23S2
Molecular Mass
1817.12 g/mol
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Research
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No listings found for HGH Fragment 176-191.
Related Compounds
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AOD-9604 is a modified 16-amino acid fragment of the C-terminal region of human growth hormone (residues 176-191) with an additional tyrosine at the N-terminus and a disulfide bond.
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Research Tools
Frequently Asked Questions
What is HGH Fragment 176-191 used for in research?
HGH Fragment 176-191 is a stabilized peptide fragment of the C-terminus of human growth hormone, corresponding to amino acids 176–191 with a tyrosine addition at the N-terminus. It retains the lipolytic activity of full GH but lacks GH's effects on insulin resistance, IGF-1 stimulation, and cellular proliferation. Developed specifically as a safer fat-loss alternative to HGH.
What forms does HGH Fragment 176-191 come in?
HGH Fragment 176-191 is available in vials, capsules, and sprays forms.
How much does HGH Fragment 176-191 cost?
Pricing varies by vendor and form.
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Research Score
2 PubMed studies
Quality Indicators
Data Completeness
63%Research Credibility
Limited research available
Quick Facts
Molecular Weight
1817.12 g/mol
CAS Number
66004-57-7
Trial Phase
Phase 2
Safety Profile
Low RiskCommon Side Effects
- • Mild hypoglycemia (dose-dependent)
- • Redness at injection site
- • Headache
Stop Use If
- Type 1 diabetes (hypoglycemia risk)
- Active malignancy
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.